Perhaps the next big mapping project in biology is the human proteome, the characterization of every human protein. A new study published in Nature announces a significant leap forward in mapping the human proteome, using artificial intelligence (AI), specifically AlphaFold2 developed by DeepMind. “After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure1. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins). This is not the same thing as saying we know the structure of 58% of human proteins, because the database covers portions of 98.5% of human proteins.