If, in the days ahead, either of these independent bodies are sidelined, ignored or in any way circumvented, a red line will have been crossed, and the safety and/or efficacy of a coronavirus vaccine can reasonably be questioned. For the CDC, it’s the Advisory Committee on Immunization Practices, or ACIP, which next meets October 28–30. The 15 voting members on each advisory committee all undergo conflict-of-interest reviews, with annual filings to safeguard compliance. Today, only about half of adults in the U.S. say they would get a coronavirus vaccine if one became available this year. Unless public trust improves, the U.S. likely will see thousands of avoidable deaths and needless suffering.