Endless news cycles and viral social media warn of “breakthrough infections” in people already vaccinated for COVID-19. Influenza vaccines are the inoculations that are most associated with breakthrough infections. The COVID vaccines appear to be faring better than those for influenza usually do. Other factors contribute to an overrepresentation of vaccinated patients with breakthrough infections, including age and health conditions associated with a weakened immune system. Talaat points to reports of good responses to a third COVID vaccine dose in patients who had an organ transplant.