Now, a new test of defiance and simultaneous allegiance to the Republican Party has emerged in the form of resisting COVID-19 vaccines. At least one in four Republican House members will refuse COVID-19 vaccines. Historically, antiscience was not a major element of the Republican Party. The full antiscience agenda of the Republican Party has now gone beyond our national borders. Public refusal of COVID-19 vaccines now extends to India, Brazil, South Africa and many low- and middle-income countries.